Dear doctor we have a patient of schizophrenia having auditory hallucinations and is under medication. She is 35 and is taking alkepin 200 mg. We have come to know about DHA derivatives of clozapine (clozaprexine) which is considered to be highly safe and with high bioavailability. You are requested to kindly help us by informing availability of clozaprexine in India. We will be highly obliged and thankful to you.
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Mr. lybrate-user, I would like to tell one thing, schizophrenia is chronic illness. Basically it requires anti psychotic drugs for treatment. There are numbers of anti psychotic drugs availabale in market for treatment of Schizophrenia. Some drugs are FDA approved, some are superior in one trial but not in other trial. Some are popular in few countries but not FDA approved. Actually selection of proper antipsychotic depends on number of conditions viz. Age, sex, duration of illness, associated co morbid condition, any medical condition, substance history, organicity, prior drug response, socio-economical status etc. As in your case female patient having auditory hallucinations, probably case of schizophrenia needs proper medication consedering above mentioned condition. Now come to your basic question, she is taking clozapine 200 mg. It is also very efficacious drug. You talked about clozaprexine. It is considered as a prodrug of clozapine. It is investigational new drug, originally created at Harward University. Atype of fatty acid (DHA) was added to clozapine in order to increase penetration of blood brain barrier. This drug was initially tested in rats, but no obvous findings have been found in subsequent studies. It is not currently available in INDIA. Ihope it might help you.
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